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Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.
Sharabi K, Lin H, Tavares CD, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P.
Cell. 2017 Mar 23;169(1):148-160.
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.
Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS.
Nature. 2017 Mar 9;543(7644):252-256.
Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting.
Hatting M, Rines AK, Luo C, Tabata M, Sharabi K, Hall JA, Verdeguer F, Trautwein C, and Puigserver P.
Cell Metab. 2017 Feb 7;25(2):428-437.


Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.
Rines AK, Sharabi K, Tavares CD, Puigserver P.
Nat Rev Drug Discov. 2016 Nov;15(11):786-804.
Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations.
Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, Hollingsworth LR 4th, Jedrychowski M, Vogel R, Paulo JA, Smeitink J, Gygi SP, Doench J, Root DE, Puigserver P.
Mol Cell. 2016 Oct 6;64(1):163-175.
A PGC1α-mediated transcriptional axis suppresses melanoma metastasis.
Luo C, Lim JH, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P.
Nature. 2016 Aug 31;537(7620):422-426.
Breaking BRAF(V600E)-drug resistance by stressing mitochondria.
Luo C, Puigserver P, Widlund HR.
Pigment Cell Melanoma Res. 2016 Jul;29(4):401-3.
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.
Tavares CD, Sharabi K, Dominy JE, Lee Y, Isasa M, Orozco JM, Jedrychowski MP, Kamenecka TM, Griffin PR, Gygi SP, Puigserver P.
J Biol Chem. 2016 May 13;291(20):10635-45.
Stem cells: Dietary fat promotes intestinal dysregulation.
Luo C, Puigserver P.
Nature. 2016 Mar 3;531(7592):42-3.
Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation.
Lee G, Won HS, Lee YM, Choi JW, Oh TI, Jang JH, Choi DK, Lim BO, Kim YJ, Park JW, Puigserver P, Lim JH.
Sci Rep. 2016 Jan 7;6:18928.


Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth.
Balsa-Martinez E, Puigserver P.
Mol Cell. 2015 Nov 19;60(4):509-11.
Molecular pathophysiology of hepatic glucose production.
Sharabi K, Tavares CD, Rines AK, Puigserver P.
Mol Aspects Med. 2015 Dec;46:21-33.


Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity.
Verdeguer F, Soustek MS, Hatting M, Blättler SM, McDonald D, Barrow JJ, Puigserver P.
Mol Cell Biol. 2015 Oct 26;36(1):184-96.
Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity.
Soustek MS, Puigserver P.
EMBO J. 2015 Apr 15;34(8):981-3.
Adenosine activates thermogenic adipocytes.
Rines AK, Verdeguer F, Puigserver P.
Cell Res. 2015 Feb;25(2):155-6.


Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.
Yoonjin Lee, John E. Dominy, Yoon Jong Choi, Michael Jurczak, Nicola Tolliday, Joao Paulo Camporez, Helen Chim, Ji-Hong Lim, Hai-Bin Ruan, Xiaoyong Yang, Francisca Vazquez, Piotr Sicinski, Gerald I. Shulman, Pere Puigserver.
Nature. 2014 Jun 26;510(7506):547-51
Targeting mitochondrial oxidative metabolism in melanomas causes metabolic compensation through glucose and glutamine utilization.
Lim JH, Luo C, Vazquez F, Puigserver P.
Cancer Res. 2014 Jul 1;74(13):3535-45. 
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB.
Nature. 2014 Apr 10;508(7495):258-62.
USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy.
Hall JA, Tabata M, Rodgers JT, Puigserver P.
Mol Endocrinol. 2014 Jun;28(6):912-24.
Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms.
Verdeguer F, Blättler SM, Cunningham JT, Hall JA, Chim H, Puigserver P.
Mol Endocrinol. 2014 Mar;28(3):308-16. 
Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex.
Tabata M, Rodgers JT, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P.
Diabetes. 2014 May;63(5):1519-32. 


In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity.
Dominy J, Puigserver P, Cantó C.
Methods Mol Biol. 2013;1077:217-37.
Mitochondrial biogenesis through activation of nuclear signaling proteins.
J. E. Dominy and P. Puigserver
Cold Spring Harb Perspect Biol. 2013 Jul 1;5(7).

The sirtuin family’s role in aging and age-associated pathologies
J. Hall, J. Dominy, Y. Lee and P. Puigserver
J. Clin. Invest. 123(3):973-9, 2013

PGC1α expression defines a subset of human melanoma tumors with Increased mitochondrial capacity and resistance to oxidative stress
F. Vazquez, J.H. Lim, H. Chim, K. Bhalla, G. Girnun, C.B. Clish, S.R. Granter, H.R. Windlund, B.M. Spiegelman and P. Puigserver
Cancer Cell. 23(3):287-301, 2013

Oleic acid stimulates complete oxidation of fatty acids through PKA-dependent activation of SIRT1/PGC1α complex
J.H. Lim, Z. Gerhart-Hines, J.E. Dominy, Y. Lee, S. Kim, M. Tabata, Y.K. Xiang and P. Puigserver
J. Biol. Chem. 288(10):7117-26, 2013


The deacetylase SirT6 activates GCN5 and suppresses PGC-1α -mediated hepatic gluconegeonesis
J.E. Dominy, Y. Lee, M.J. Jedrychowski, H. Chim, M.J. Jurczak, J.P. Camporez, H.B. Ruan, J. Feldman, K. Pierce, R. Mostoslavsky, J.M. Denu, C.B. Clish, X. Yang, G.I. Shulman, S.P. Gygi and P. Puigserver
Molecular Cell. 48(6):900-13, 2012

Defective mitochondrial dynamics and bioenergetic function in mice lacking the transcription factor YY1 in skeletal muscle
S.M. Blättler, F. Verdeguer, J.T. Cunningham, H. Chim, M. Ruegg, Y. Shi and P. Puigserver
Mol Cell Biol.32(16):3333-46,2012

Ying Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF Signaling
S.M. Blättler, J.C. Cunningham, F. Verdeguer, H. Chim, W. Haas, M. Ruegg, H. Liu, S.P. Gygi, Y. Shi andP. Puigserver
Cell Metabolism. 4;15(4):505-17, 2012

Signaling transduction and regulation of cell metabolism
P. Puigserver
Hematology 6e. Edited by Ed Benz, Les Silberstein, Helen Heslop. Ron Hoffman, Jeff Weitz. 2012

TRPV4 is a regulator of adipose oxidative metabolism, inflammation and energy homeostasis
L. Ye, S. Kleiner, J. Wu, R. Sah, R.K. Gupta, A.S. Banks, P. Cohen, M.J. Khandekar, P. Bostrom, R.J. Mepani, D. Laznik, T.M. Kamenecka, X. Song, W. Liedtke, V.K. Mootha, P. Puigserver, P.R. Griffin, D.E. Claphan and B.M. Spiegelman
Cell. 151(1) 96-110, 2012

PPARδ and fatty acid oxidation regulate haematopoietic stem cell maintenance through the control of asymmetric cell division
K. Ito, A. Carracedo, D. Weiss, V.C.J. De Boer, F. Arai, D.E. Avigan, Z. Gerhart-Hines, P. Puigserver, Z.T. Schafer, R.M. Evans, T. Suda, C.H. Lee, M.C. Haigis and P.P. Pandolfi
J Clin Invest. 122(9):3088-100, 2012

Glycine decarboxylase cleaves a “malignant” metabolic path to promote tumor initiation
J. Dominy, F. Vazquez and P. Puigserver
Cancer Cell. 21(2):143-5. 2012


The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD+
Z. Gerhart-Hines, J.E. Dominy, S.M. Blättler, M.P. Jedrychowski, A.S. Banks, J.H. Lim, H. Chim, S.P. Gygi andP. Puigserver
Molecular Cell. 44(6):851-63, 2011

A hypoxia induced positivefeedback loop promotes HIF-1α stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like
T.J. Kelly, A. Souza, C. Clish and P. Puigserver
Mol. Cell Biol. 31(13):2696-2706, 2011

Clk2 and B56β mediate insulin regulated assembly of the PP2A holoenzyme Complex on Akt
J.T. Rodgers, R. Voegel and P. Puigserver
Molecular Cell. 41(4):471-9, 2011

Nuclear chromatin factors defining mitochondrial bioenergetics: implications in age-associated diseases
P. Puigserverand L. Guarente
In: Mitochondrial Signaling in Health and Diseases. Edited by Sten Orrenius and E. Cadenas. 2011

Nutrient-dependent acetylation controls basic regulatory switches and cellular reprogramming
J. E. Dominy, Z. Gerhart-Hines and P. Puigserver
Cold Spring Harb Symp Quant Biol.76:203-9, 2011

PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis
K. Bhalla, B.J. Hwang, R. Dewi, L. Ou, W. Twaddel, H.B. Fang, S. Vafai, F. Vazquez, P. Puigserver, L.G. Boros and G. Girnun
Cancer Res. 71(21):6888-98, 2011

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function
K. Romanino, L. Mazelin, V. Albert, A. Duplany, S. Lin, C.F. Bentzinger, C. Handschin, P. Puigserver, L. Schaeffer, Y.G. Gangloff and M. Ruegg
Proc. Natl. Acad. Sci. USA. 108(51):20808-13, 2011


Cdc2-like kinase 2 is an insulin regulated suppressor of hepatic gluconeogenesis.
J.T. Rodgers, W. Haas, S.P. Gygi and P. Puigserver
Cell Metabolism. 11(1), 23-34, 2010

Nutrient-dependent regulation of PGC-1alpha’s acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5
J.E. Dominy, Y. Lee, Z. Gerhart-Hines and P. Puigserver
Biochim Biophys Acta. 1804(8):1676-83, 2010

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
A.K. Walker, F. Yang, K. Jiang, J.Y. Ji, J.L. Watts, A. Purushotham, O. Boss, M.L. Hirsch, S. Ribich, J.J. Smith, K. Israelian, C.H. Westphal, J.T. Rodgers, T. Shioda, S. Elson, P. Mulligan, H. Najafi-Shoushtari, J.C. Black, J.K. Thakur, L.C. Kadyk, J. Whetstine, R. Mostoslavsky, P. Puigserver, X. Li, N.J. Dyson, A.C. Hart, and A.M. Näar Genes Dev. 24(13):1403-17, 2010

Nuclear FoxO1 inflames insulin resistance
J. Dominy and P. Puigserver
EMBO J. 29:4068-9, 2010


GCN5-mediated transcriptional control of the metabolic coactivator PGC-1β through lysine acetylation.
T.J. Kelly, C. Lerin, W. Haas, S.P. Gygi, and P. Puigserver
J. Biol. Chem. 284(30):19945-52, 2009

Foxo1 integrates insulin signaling with mitochondria function in the liver
Z. Cheng, S. Guo, K. Copps, X. Dong, R. Kollipara, J.T. Rodgers, R.A. DePinho, P. Puigserver and M.F. White
Nature Medicine. 15(11):1307-11, 2009

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachments
Z.T. Schafer, A.R. Grassian, L. Song, Z. Jiang, Z. Gerhart-Hines, H.Y. Irie, S. Gao, P. Puigserver and J. S. Brugge
Nature. 461(7260):109-13, 2009

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
C. Canto, Z. Gerhart-Hines, J.N. Feige, M. Lagouge, J.C. Milne, L. Noriega, P.J. Elliott, P. Puigserver and J. Auwerx
Nature. 458(7241):1056-60, 2009

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
G. Suchankova, L. Nelson, Z. Gerhart-Hines, M. Kelly, M.S. Gauthier, A.K Saha, Y. Ido, P. Puigserver and N.B. Ruderman
Biochem. Biophys. Res. Commun. 378:836-41, 2009


Metabolic adaptations  through PGC-1α and SIRT1 pathways
J. T. Rodgers, C. Lerin, Z. Gerhart-Hines and P. Puigserver
FEBS Letters. 582: 46-53, 2008

A PGC-1a:O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose
M.P. Housley, N.D. Udeshi, J.T. Rodgers, J. Shabanowitz, P. Puigserver, D.F. Hunt and G.W. Hart
J. Biol. Chem. 284(8):5148-57, 2008

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1α
A. Coste, J.F. Louet , M. Lagouge , C. Lerin , M. Antal , H. Meziane , K. Schoonjans , P. Puigserver, B. O’Malley and J. Auwerx
Proc. Natl. Acad. Sci. USA. 105(44):17187-92, 2008

O-GlcNAc regulates FoxO activation in response to glucose
M.P. Housley, J.T. Rodgers, N.D. Udeshi, T.J. Kelly, J. Shabanowitz, D.F. Hunt, P. Puigserver and G.W. Hart
J. Biol. Chem. 283(24):16283-92, 2008


mTOR controls mitochondrial oxidative function through a YY1/PGC-1α complex
J.T. Cunningham, J.T. Rodgers, D. Arlow, F. Vazquez, V.K. Mootha and P. Puigserver
Nature. 450, 736-740, 2007

Fasting-dependent glucose and lipid metabolic response through hepatic SIRT1
J.T. Rodgers and P. Puigserver
Proc. Natl. Acad. Sci. USA. 104(31) 12861-66, 2007

Metabolic control of mitochondrial function and fatty acid oxidation through PGC-1α /SIRT1
Z.Gerhart-Hines, J.T. Rodgers,O. Bare, C. Lerin, S.H. Kim, R. Mostoslavsky, F.W. Alt, Z. Wu and P. Puigserver
EMBO J. 26, 1913-1923, 2007

Mammalian metabolism in aging
P. Puigserverand C.R. Kahn
Edited by L. Guarente, L. Partridge and D.C. Wallace
Molecular Biology of Aging. Cold Spring Harbor Monograph Series 51. 2007

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
D. Kim, M.D. Nguyen, M.M. Dobbin, A. Fisher, F. Sananbesi, J.T. Rodgers, I. Delalle, J.A. Baur, G. Sui, S.M. Armour, P. Puigserver, D.A. Sinclair and L.H. Tsai
EMBO J. 26(13):3169-79, 2007

Receptor feasts on sugar and cholesterol
J. T. Rodgers and P. Puigserver
Nature Medicine. 13(2):128-129, 2007


GCN5 acetyl transferase complex controls glucose metabolism through transcriptional repression of PGC-1α
C. Lerin, J.T. Rodgers, D. Kalume, S.H. Kim, A. Pandey andP. Puigserver
Cell Metabolism. 3(6):429-38, 2006

Resveratrol promotes mitochondrial biogenesis and protects against metabolic disease through activating SIRT1 and PGC-1α activity
M. Lagouge, C. Argmann, Z. Gerhart-Hines, H. Meziane, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, C. Lerin, B. Geny, M. Laakso, P. Puigserver and J. Auwerx Cell. 127(6):1109-22, 2006

Resveratrol improves health and survival of mice on a high-calorie diet
J.A. Baur, K.J. Pearson, N.L. Price, H.A. Jamieson, C. Lerin, A. Kalra, V.V. Prabhu, J.S. Allard, G. Lopez-Lluch, K. Lewis, P.J. Pistell, S.Poosala, K.G. Becker, O. Boss, D. Gwinn, M. Wang, S. Ramaswamy, K.W. Fishbein, R.G. Spencer, E.G. Lakatta, D. Le Couteur, R.J. Shaw, P. Navas, P. Puigserver, D.K. Ingram, R. de Cabo and D.A. Sinclair
Nature. 444(7117):337-42, 2006

Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: role of PGC-1α
S.H. Cha, J.T. Rodgers, P. Puigserver, S. Chohnan and M.D. Lane
Proc. Natl. Acad. Sci. USA. 103(42):15410-5, 2006

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer’s disease and amyloid neuropathology by calorie restriction
W.Qin, T. Yang, L. Ho, Z. Zhao, J. Wang, L. Chen, M. Thiyagarajan, D. Macgrogan, J.T. Rodgers, P. Puigserver, J. Sadoshima, H.H. Deng, S. Pedrini, S. Gandy, A. Sauve and G.M. Pasinetti
J. Biol. Chem. 281(31):21745-54, 2006

Foxa2, a novel transcriptional regulator of insulin sensitivity
P. Puigserver and J.T. Rodgers
Nature Medicine. 12(1):38-9, 2006

Certainly you can’t live without it: SIRT6
J. T. Rodgers and P. Puigserver
Cell Metabolism. 3(2):77-8, 2006


Nutrient control of gluconeogenesis through PGC-1α/SIRT1 deacetylase complex
J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman and P. Puigserver
Nature. 434:113-8, 2005

Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC-1α
P. Puigserver
Int. J. Obes. Relat. Metab. Disord. 29: S5-9, 2005


PGC-1α: Metabolic Regulator and Transcriptional Coactivator
B.M. Spiegelman and P. Puigserver
Endocr. Rev. 24(1): 78-90, 2003

ERRα and Gabpα/β specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
V.K. Mootha, C. Handschin, D. Arlow, X. Xie, J. St Pierre, S. Sihag, W. Yang, D. Altshuler, P. Puigserver, N. Patterson, P.J. Willy, I.G. Schulman, R.A. Heyman, E.S. Lander and B.M. Spiegelman
Proc. Natl. Acad. Sci. USA. 101:6570-5, 2004

p38 mitogen-activated protein kinase is the central regulator of cAMP-dependent transcription of the brown fat uncoupling protein 1 gene
W. Cao, K.W. Daniel, J. Rabidoux, P. Puigserver, A.V. Medvedev, X. Bai, L.M. Floering, B.M. Spiegelman and S. Collins
Mol. Cell Biol. 24:3057-3067, 2004

Suppression of mitochondrial respiration via p160 Myb binding protein docking on PGC-1α: modulation by p38 MAPK
M. Fan, J. Rhee, J. St-Pierre, C. Handshin, P. Puigserver, J. Lin, S. Jaeger, H. Erdjument-Bromage, P. Tempst and B.M. Spiegelman
Genes Dev. 18: 278-289, 2004

Suppression of beta-cell energy metabolism and insulin release by PGC-1α
J. Cliff Yoon, G. Xu, J.T. Deeny, S. Yang, J. Rhee, P. Puigserver, R. Yang, C. Zhang, B.B. Lowell, P.O. Berggren, C.B. Newgard, S. Bonner-Weir, G. Weir and B.M. Spiegelman
Dev. Cell. 5, 73-83, 2003

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
V.K. Mootha, C.M. Lindgren, K.F. Eriksson, A. Subramanian, S. Sihag, P. Puigserver, E. Carlsson, M. Ridderstrale, E. Laurila, N. Houstis, M.J. Daly, N. Patterson, J.P. Mesirov, T.R. Golub, P. Tamayo, B.M. Spiegelman, E.S. Lander, J.N. Hirschhorn, D. Altshuler and L.C. Groop
Nat. Genet. 34, 267-273, 2003

PGC-1β in the regulation of hepatic glucose and energy metabolism
J. Lin, P.T. Tarr, R. Yang, J. Rhee, P. Puigserver, C.B. Newgard and B.M. Spiegelman J. Biol. Chem. 278, 30843-8, 2003

Insulin-regulated hepatic gluconeogenesis through FOXO1/PGC-1α interaction
P. Puigserver, J. Rhee, J. Donovan, C.J. Walkey, J.C. Yoon, F. Oriente, Y. Kitamura, J. Altomonte, H. Dong, D. Accili and B.M. Spiegelman
Nature. 423, 550-5, 2003

Regulation of hepatic fasting response by PPARgamma coactivator-1 alpha (PGC-1α): Requirement for hepatocyte nuclear factor 4 alpha in gluconeogenesis
J. Rhee, Y. Inoue, J.C. Yoon, P. Puigserver, M. Fan, F.J. Gonzalez and B.M. Spiegelman
Proc. Natl. Acad. Sci. USA. 100, 4012-7, 2003

Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC-1α) expression in the murine brain
N.A. Tritos, J.W. Mastaitis, E.G. Kokkotou, P. Puigserver, B.M. Spiegelman and E. Maratos-Flier
Brain Res. 961, 255-60, 2003

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibers
J. Lin, H. Wu, P. Tarr, C.Y. Zhang, Z. Wu, O. Boss, L.F. Michael, P. Puigserver, E. Isotani, E. N. Olson, B. Lowell, R. Bassel-Duby and B.M. Spiegelman
Nature. 418, 797-801, 2002

PGC-1β: A novel transcription coactivator associated with host cell factor
J. Lin, P. Puigserver, J. Donovan, P. Tarr and B.M. Spiegelman
J. Biol. Chem. 277, 1645-1648, 2002

Cytokine-activation of energy expenditure through p38 MAP kinase phosphorylation of the PPARγ coactivator (PGC-1)
P. Puigserver, J. Rhee, J. Lin, Z. Wu, J.C. Yoon, C. Zhang, S. Krauss, V. Mootha. B.B. Lowell and B.M. Spiegelman
Mol. Cell. 8, 971-982, 2001

CREB regulates hepatic gluconeogenesis via the co-activator PGC-1
S. Herzig, F. Long, U. Jhala, S. Hedrick, R. Quinn, A. Bauer, D. Rudolph, G. Schutz, J.C. Yoon, P. Puigserver, B.M. Spiegelman and M. Montminy
Nature. 413:179-183, 2001

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
J.C. Yoon, P. Puigserver, G. Chen, Z. Wu, J. Rhee, G. Adelmant, J. Stafford, C.R. Kahn, K. Granner, C.B. Newgard, and B.M. Spiegelman
Nature. 413:131-138, 2001.

Restoration of insulin-sensitive glucose transporter (GLUT-4) gene expression in muscle cells by the transcriptional coactivator PGC-1
L.F. Michael, Z. Wu, R.B. Cheatham, P. Puigserver, G. Adelmant, J.J. Lehman, D.P. Kelly, and B.M. Spiegelman
Proc. Natl. Acad. Sci. USA. 98:3820-3825, 2001

Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1
M. Monsalve, Z. Wu, G. Adelmant, P. Puigserver, M. Fan, and B.M. Spiegelman
Mol. Cell.  6:307-316, 2000

Regulation of adipogenesis and energy balance by PPARγ and PGC-1
B. M. Spiegelman, P. Puigserver and Z. Wu
Int. J. Obes. Relat. Metab. Disord. 24 (4): S8-10, 2000.

Regulation of adipogenesis and energy balance by PPARγ and PGC-1
I. Tcherepanova, P. Puigserver, J. Norris, B.M. Spiegelman and D. McDonnell
J. Biol. Chem. 275 (21) 16302-16308, 2000

Transcriptional regulation of adipogenesis
E.D. Rosen, C.J. Walkey, P. Puigserver and B.M. Spiegelman
Genes Dev. 14: 1295-1307, 2000

Activation of PPARγ Coactivator (PGC-1) through transcription factor docking
P. Puigserver, G. Adelmant, Z. Wu, M. Fan, J. Xu, B. O’Malley and B.M. Spiegelman Science. 286(5443):1368-71,1999

Transcriptional activation of adipogenesis
Z. Wu, P. Puigserver and B. M. Spiegelman
Curr. Opin. Cell Biol. 11(6): 689-94, 1999

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
Z. Wu, P. Puigserver, U. Andersson, C. Zhang, G. Adelmant, V. Mootha, A. Troy, S. Cinti, B. Lowell, R. Scarpulla and B.M. Spiegelman
Cell. 98:115-24, 1999

Stimulation of uncoupling protein 1 expression in brown adipocyte by naturally occurring carotenoids
F. Serra, M.L. Bonet, P. Puigserver, J. Oliver and A. Palou
Int. J. Obes. Relat. Metab. Disord.  23:650-5, 1999

Regulation of energy balance by PPARγ and its coactivators
B.M. Spiegelman, G. Castillo, S. Hauser and P. Puigserver
Progress in Obesity Research: 8, 39-46, 1999

A cold-inducible nuclear receptor coactivator linked to adaptive thermogenesis
P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright and B.M. Spiegelman
Cell. 92, 829-839, 1998

Involvement of the retinoblastoma protein in brown and white adipocyte cell differentiation: functional and physical association with the adipogenic transcription factor C/EBPα
P. Puigserver, J. Ribot, F. Serra, M. Gianotti, M.L. Bonet, B. Nadal-Ginard and A. Palou
Eur. J. Cell Biol.  77(2), 117-123, 1998          

2-methoxyoestradiol, an endogenous metabolite of 17-β-estradiol, inhibits adipocyte proliferation
C. Pico, P. Puigserver, P. Oliver and A. Palou
Mol. Cell. Biochem. 189, 1-7, 1998

Retinoic acid modulates RARα and RXRα levels in cultured brown adipocytes
M.L. Bonet, P. Puigserver, F. Serra, F. Vazquez, C. Pico and A. Palou
FEBS Lett.  406, 196-200, 1997

Diminished response to food deprivation of the rat brown adipose tissue mitochondrial uncoupling system with age
F.J. Garcia-Palmer, J. Pericas, J.C. Matamala, P. Puigserver, M.L. Bonet, A Palou and M. Gianotti
Biochem. Mol. Biol. Int. 42, 1151-1161, 1997

In vitro an in vivo induction of the uncoupling protein thermogenin by retinoids
P. Puigserver, F. Vazquez, M.L. Bonet, C. Pico and A. Palou
Biochem. J. 317, 827-833, 1996

Effect of selective ß-adrenoceptor stimulation on UCP expression in primary cultures of brown adipocytes
P. Puigserver, C. Pico, M.J. Stock and A. Palou
Mol. Cell Endocrinol. 117, 7-16, 1996

Cold exposure induces different uncoupling-protein thermogenin masking/unmasking processes in brown adipose tissue depending on mitochondrial subtypes
M. Moreno, P. Puigserver, J. Llull, M. Gianotti, A. Lanni, F. Goglia and A. Palou
Biochem. J. 300, 2, 463-468, 1994

Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in-vitro and in-vivo: evidence for a rapidly degradable pool
P. Puigserver, D. Herron, M. Gianotti, A. Palou, B. Cannon and J. Nedergaard
Biochem. J. 284, 393-398, 1992

Dietary regulation of fasting-induced mitochondrial protein degradation in adult rat brown adipose tissue
P. Puigserver, A. Palou and M. Gianotti
Biochem. Int. 27, 1037-1046, 1992

Impaired starvation-induced loss of mitochondrial protein in the brown adipose tissue of dietary obese rats
P. Puigserver, A. Palou and M. Gianotti
Int. J. Obes. 16, 255-261, 1992

Adrenergic regulation of differentiation and proliferation in brown adipocyte cultures
J. Nedergaard, M. Néchad, S. Rehnmark, D. Herron, A. Jacobsson, P. Kuusela, P. Puigserver, J. Houstek, G. Bronnikov and B. Cannon
Obesity in Europe. G. Ailhaud et al. Eds. 355-361,1991

Evidence for masking of rat brown adipose tissue mitochondrial GDP-binding sites in response to fasting in rats made obese by dietary manipulation
P. Puigserver, I. Llado, A. Palou and M. Gianotti
Biochem. J. 279, 575-579, 1991