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Publications

2024

Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation
Beste Mutlu*, Kfir Sharabi*, Jee Hyung Sohn*, Bo Yuan, Pedro Latorre-Muro, Xin Qin, Jin-Seon Yook, Hua Lin, Deyang Yu, João Paulo G. Camporez, Shingo Kajimura, Gerald I. Shulman, Sheng Hui, Theodore M. Kamenecka, Patrick R. Griffin, Pere Puigserver
Cell Chem. Bio., 2024 Sept. 27; doi.org/10.1016/j.chembiol.2024.09.001
 
Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
Deyang Yu, Jiaxin Liang, Hans Widlund, Pere Puigserver
Cell Rep., 2024 July 11; doi.org/10.1016/j.celrep.2024.114484
 
Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy
Sumeet A. Khetarpal, Haobo Li, Tevis Vitale, James Rhee, Louisa Grauvogel, Claire Castro, Melanie J. Mittenbühler, Nicholas E. Houstis, Ariana Vargas-Castillo, Amanda L. Smythers, Jing Liu, Casie Curtin, Hans-Georg Sprenger, Katherine A. Blackmore, Alexandra Kuznetsov, Rebecca Freeman, Dina Bogoslavski, Patrick T. Ellinor, Aarti Asnani, Phillip A. Dumesic, Pere Puigserver, Jason D. Roh, Bruce M. Spiegelman, Anthony Rosenzweig
bioRxiv., 2024 Feb 2; doi.org/10.1101/2024.01.30.578093
 
Navigating the landscape of mitochondrial-ER communication in health and disease
Conor T Ronayne & Pedro Latorre-Muro.
Front. Mol. Biosci., 2024 Jan 23; doi.org/10.3389/fmolb.2024.1356500
 
Structural basis of respiratory complexes adaptation to cold temperatures
Young-Cheul Shin*, Pedro Latorre-Muro*, Amina Djurabekova, Oleksii Zdorevskyi, Christopher Bennett, Nils Burger, Kangkang Song, Chen Xu, Vivek Sharma, Maofu Liao, Pere Puigserver
bioRxiv., 2024 Jan 16; doi.org/10.1101/2024.01.16.575914.

2023

Tetracyclines activate mitoribosome quality control and reduce ER stress to promote cell survival
Conor T Ronayne, Thomas D Jackson, Christopher F Bennett, Elizabeth A Perry, Noa Kantorovich, Pere Puigserver 
EMBO Rep., 2023 Oct 11; doi.org/10.15252/embr.202357228.
 
Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity
Jiaxin Liang*, Tevis Vitale*, Xixi Zhang, Thomas D. Jackson, Deyang Yu, Mark Jedrychowski, Steve P. Gygi, Hans R. Widlund, Kai W. Wucherpfennig, Pere Puigserver
bioRxiv., 2023 Oct 2; doi.org/10.1101/2023.10.02.560316.
 
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.
Jee Hyung Sohn, Beste Mutlu, Pedro Latorre-Muro, Jiaxin Liang, Christopher F. Bennett, Kfir Sharabi, Noa Kantorovich, Mark Jedrychowski, Steven P. Gygi, Alexander S. Banks, Pere Puigserver 
Cell Metab., 2023 July 19; doi.org/10.1016/j.cmet.2023.06.015.
 
Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas.
Jiaxin Liang, Deyang Yu, Chi Luo, Christopher Bennett, Mark Jedrychowski, Steve P. Gygi, Hans R. Widlund, Pere Puigserver
Nat. Commun, 2023 June 5; doi.org/10.1038/s41467-023-38968-7.
 
The SLC25A47 locus controls gluconeogenesis and energy expenditure.
Jin-Seon Yook, Zachary H Taxin, Bo Yuan, Satoshi Oikawa, Christopher Auger, Beste Mutlu, Pere Puigserver, Sheng Hui, Shingo Kajimura.
Proc Natl Acad Sci U S A. 2023 Feb 28; 10.1073/pnas.2216810120.

2022

Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11.
Zhang L, Hobeika CS, Khabibullin D, Yu D, Filippakis H, Alchoueiry M, Tang Y, Lam HC, Tsvetkov P, Georgiou G, Lamb C, Stone E, Puigserver P, Priolo C, Henske EP.
Proc Natl Acad Sci U S A. 2022 Jul 12; 10.1073/pnas.2122840119
 
Mechanisms of mitochondrial respiratory adaptation.
Bennett CF, Latorre-Muro P, Puigserver P.
Nature Reviews Molecular Cell Biology. 2022 Jul 8; 10.1038/s41580-022-00506-6
 
Atossa: a royal link between OXPHOS metabolism and macrophage migration. 
Latorre-Muro P, Puigserver P.
EMBO Journal, 2022 Jun 14; 10.15252/embj.2022111290
 

2021

Controversies surrounding peripheral cannabinoid receptor 1 in fatty liver disease.
Mutlu B, Puigserver P.
Journal of Clinical Investigation. 2021 Nov 15; 10.1172/JCI154147
 
Targeting adaptive cellular responses to mitochondrial bioenergetic deficiencies in human disease.
Bennett CF, Ronayne CT, Puigserver P.
FESB Journal. 2021 Sep 12; 10.1111/febs.16195
 
Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly.
Bennett C, O'Malley KE, Perry EA, Balsa E, Latorre-Muro P, Riley CL, Luo C, Jedrychowski M, Gygi SP, Puigserver P.
Nature Chemical Biology. 2021 March 15;10.1038/s41589-021-00772-z
 
A cold-stress-inducible PERK/OGT axis control TOM70-assisted mitochondrial protein import and cristae formation.
Latorre-Muro P, O'Malley KE, Bennett C, Perry EA, Balsa E, Tavares CDJ, Jedrychowski M, Gygi SP, Puigserver P.
Cell Metabolism. 2021 Feb 9;S1550-4131(21)00013-9.
 
Tetracyclines promote survival and fitness in mitochondrial disease models.
Perry EA, Bennett C, Luo C, Balsa E, Jedrychowski M, O'Malley KE, Latorre-Muro P, Ladley RP, Reda K, Wright PM, Gygi SP, Myers AF, Puigserver P.
Nature Metabolism. 2021 Jan 17;3(1): 33-42. 
 
Structure-Activity Relationship and Biological Investigation of SR18292(16), a Suppressor of Glucagon-Induced Glucose Production.
Lin H, Sharabi K, Lin L, Ruiz C, Zhu D, Cameron MD, Novick SJ, Griffin PR, Puigserver P, Kamenecka TM.
J.Med Chem. 2021 Jan 12;64,2,980-990. 

2020

Transcription-wide analysis of PGC1-a-binding RNAs identifies gene linked to glucagon metabolic action.
Tavares CDJ, Aigner S, Sharabi K, Sathe S, Multu B, Yea GW, Puigserver P.
Pro Natl Acas Sci USA. 2020 Sep 8; 1177(36): 22204-22213
 
GCN5 Acetyltransferase in Cellular Energetic and Metabolic Processes. 
Mutlu B, Puigserver P. 
Biochim Biophys Acta. Gene Reg Mech. 2020 Aug 19:194626. 
 
Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency. 
Luo C, Liang J, Sharabi K, Hatting M, Perry EA, Tavaes CDJ, Goyal L, Srivastava A, Bilodeau M, Zhu AX, Sicinski P, Puigserver P. 
Cancer Res. 2020 Aug 15;80(16):3215-3221. 
 
Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death. 
Balsa E, Perry EA, Bennett CF, Jedrychowski M, Gygi SP, Doench JG, Puigserver P. 
Nat Commun. 2020 Jun 1;11(1):2714. 
 
H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP. 
Luo C, Balsa E, Perry E, Liang J, Tavares C, Vazquez F, Widlund H, Puigserver P. 
J Clinical Investigation. 2020 Jan 13;130(2):1-10. 
 
Autophagy mediates hepatic GRK2 degradation to facilitate glucagon-induced metabolic adaptation to fasting. 
Cruces-Sande M, Arcones AC, Vila-Bedmar R, Val-Blasco A, Sharabi K, Díaz-Rodríguez D, Puigserver P, Mayor F Jr, Murga C. 
FASEB J. 2020 Jan;34(1):339-409. 

2019

Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives. 
Sharabi K, Tavares CDJ, Puigserver P. 
Curr Diab Rep. 2019 Sep 7;19(10):98..
 
ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-elF2α Axis. 
Balsa E, Soustek MS, Thomas A, Cogliati S, Garcia-Poyatos C, Martin-Garcia E, Jedrychoqski M, Gygi SP, Enriquez JA, Puigserver P. 
Mol Cell. 2019 Jun 6;74(5):877-890. 

2018

Inhibition of the ER stress IRE1α inflammatory pathway protects against cell death in mitochondrial complex I mutant cells. 
Soustek MS, Balsa E, Barrow JJ, Jedrychowski M, Vogel R, Jan Smeitink, Gygi SP,  Puigserver P. 
Cell Death Dis. 2018 May 31;9(6):658. 
 
Insulin Regulation of Gluconeogenesis. 
Hatting M, Tavares CDJ, Sharabi K, Rines AK, Puigserver P. 
Ann N Y Acad Sci. 2018 Jan;1411(1):21-35.

2017

ERRα Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1α-Elevated Melanomas. 
Luo C, Balsa E, Thomas A, Hatting M, Jedrychowski M, Gygi SP, Widlund HR, Puigserver P.
Mol Cancer Res. 2017 Oct;15(10):1366-1375. 
 
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.
Sharabi K, Lin H, Tavares CD, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P.
Cell. 2017 Mar 23;169(1):148-160.
 
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.
Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS.
Nature. 2017 Mar 9;543(7644):252-256.
 
Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting.
Hatting M, Rines AK, Luo C, Tabata M, Sharabi K, Hall JA, Verdeguer F, Trautwein C, and Puigserver P.
Cell Metab. 2017 Feb 7;25(2):428-437.

2016

Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.
Rines AK, Sharabi K, Tavares CD, Puigserver P.
Nat Rev Drug Discov. 2016 Nov;15(11):786-804.
 
Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations.
Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, Hollingsworth LR 4th, Jedrychowski M, Vogel R, Paulo JA, Smeitink J, Gygi SP, Doench J, Root DE, Puigserver P.
Mol Cell. 2016 Oct 6;64(1):163-175.
 
A PGC1α-mediated transcriptional axis suppresses melanoma metastasis.
Luo C, Lim JH, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P.
Nature. 2016 Aug 31;537(7620):422-426.
 
Breaking BRAF(V600E)-drug resistance by stressing mitochondria.
Luo C, Puigserver P, Widlund HR.
Pigment Cell Melanoma Res. 2016 Jul;29(4):401-3.
 
The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.
Tavares CD, Sharabi K, Dominy JE, Lee Y, Isasa M, Orozco JM, Jedrychowski MP, Kamenecka TM, Griffin PR, Gygi SP, Puigserver P.
J Biol Chem. 2016 May 13;291(20):10635-45.
 
Stem cells: Dietary fat promotes intestinal dysregulation.
Luo C, Puigserver P.
Nature. 2016 Mar 3;531(7592):42-3.
 
Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation.
Lee G, Won HS, Lee YM, Choi JW, Oh TI, Jang JH, Choi DK, Lim BO, Kim YJ, Park JW, Puigserver P, Lim JH.
Sci Rep. 2016 Jan 7;6:18928.

2015

Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth.
Balsa-Martinez E, Puigserver P.
Mol Cell. 2015 Nov 19;60(4):509-11.
 
Molecular pathophysiology of hepatic glucose production.
Sharabi K, Tavares CD, Rines AK, Puigserver P.
Mol Aspects Med. 2015 Dec;46:21-33.

 

Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity.
Verdeguer F, Soustek MS, Hatting M, Blättler SM, McDonald D, Barrow JJ, Puigserver P.
Mol Cell Biol. 2015 Oct 26;36(1):184-96.
 
Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity.
Soustek MS, Puigserver P.
EMBO J. 2015 Apr 15;34(8):981-3.
 
Adenosine activates thermogenic adipocytes.
Rines AK, Verdeguer F, Puigserver P.
Cell Res. 2015 Feb;25(2):155-6.

2014

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.
Yoonjin Lee, John E. Dominy, Yoon Jong Choi, Michael Jurczak, Nicola Tolliday, Joao Paulo Camporez, Helen Chim, Ji-Hong Lim, Hai-Bin Ruan, Xiaoyong Yang, Francisca Vazquez, Piotr Sicinski, Gerald I. Shulman, Pere Puigserver.
Nature. 2014 Jun 26;510(7506):547-51
 
Targeting mitochondrial oxidative metabolism in melanomas causes metabolic compensation through glucose and glutamine utilization.
Lim JH, Luo C, Vazquez F, Puigserver P.
Cancer Res. 2014 Jul 1;74(13):3535-45. 
 
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB.
Nature. 2014 Apr 10;508(7495):258-62.
 
USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy.
Hall JA, Tabata M, Rodgers JT, Puigserver P.
Mol Endocrinol. 2014 Jun;28(6):912-24.
 
Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms.
Verdeguer F, Blättler SM, Cunningham JT, Hall JA, Chim H, Puigserver P.
Mol Endocrinol. 2014 Mar;28(3):308-16. 
 
Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex.
Tabata M, Rodgers JT, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P.
Diabetes. 2014 May;63(5):1519-32. 

2013

In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity.
Dominy J, Puigserver P, Cantó C.
Methods Mol Biol. 2013;1077:217-37.
 
Mitochondrial biogenesis through activation of nuclear signaling proteins.
J. E. Dominy and P. Puigserver
Cold Spring Harb Perspect Biol. 2013 Jul 1;5(7).
 

The sirtuin family’s role in aging and age-associated pathologies
J. Hall, J. Dominy, Y. Lee and P. Puigserver
J. Clin. Invest. 123(3):973-9, 2013

PGC1α expression defines a subset of human melanoma tumors with Increased mitochondrial capacity and resistance to oxidative stress
F. Vazquez, J.H. Lim, H. Chim, K. Bhalla, G. Girnun, C.B. Clish, S.R. Granter, H.R. Windlund, B.M. Spiegelman and P. Puigserver
Cancer Cell. 23(3):287-301, 2013

Oleic acid stimulates complete oxidation of fatty acids through PKA-dependent activation of SIRT1/PGC1α complex
J.H. Lim, Z. Gerhart-Hines, J.E. Dominy, Y. Lee, S. Kim, M. Tabata, Y.K. Xiang and P. Puigserver
J. Biol. Chem. 288(10):7117-26, 2013

2012

The deacetylase SirT6 activates GCN5 and suppresses PGC-1α -mediated hepatic gluconegeonesis
J.E. Dominy, Y. Lee, M.J. Jedrychowski, H. Chim, M.J. Jurczak, J.P. Camporez, H.B. Ruan, J. Feldman, K. Pierce, R. Mostoslavsky, J.M. Denu, C.B. Clish, X. Yang, G.I. Shulman, S.P. Gygi and P. Puigserver
Molecular Cell. 48(6):900-13, 2012

Defective mitochondrial dynamics and bioenergetic function in mice lacking the transcription factor YY1 in skeletal muscle
S.M. Blättler, F. Verdeguer, J.T. Cunningham, H. Chim, M. Ruegg, Y. Shi and P. Puigserver
Mol Cell Biol.32(16):3333-46,2012

Ying Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF Signaling
S.M. Blättler, J.C. Cunningham, F. Verdeguer, H. Chim, W. Haas, M. Ruegg, H. Liu, S.P. Gygi, Y. Shi andP. Puigserver
Cell Metabolism. 4;15(4):505-17, 2012

Signaling transduction and regulation of cell metabolism
P. Puigserver
Hematology 6e. Edited by Ed Benz, Les Silberstein, Helen Heslop. Ron Hoffman, Jeff Weitz. 2012

TRPV4 is a regulator of adipose oxidative metabolism, inflammation and energy homeostasis
L. Ye, S. Kleiner, J. Wu, R. Sah, R.K. Gupta, A.S. Banks, P. Cohen, M.J. Khandekar, P. Bostrom, R.J. Mepani, D. Laznik, T.M. Kamenecka, X. Song, W. Liedtke, V.K. Mootha, P. Puigserver, P.R. Griffin, D.E. Claphan and B.M. Spiegelman
Cell. 151(1) 96-110, 2012

PPARδ and fatty acid oxidation regulate haematopoietic stem cell maintenance through the control of asymmetric cell division
K. Ito, A. Carracedo, D. Weiss, V.C.J. De Boer, F. Arai, D.E. Avigan, Z. Gerhart-Hines, P. Puigserver, Z.T. Schafer, R.M. Evans, T. Suda, C.H. Lee, M.C. Haigis and P.P. Pandolfi
J Clin Invest. 122(9):3088-100, 2012

Glycine decarboxylase cleaves a “malignant” metabolic path to promote tumor initiation
J. Dominy, F. Vazquez and P. Puigserver
Cancer Cell. 21(2):143-5. 2012

2011

The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD+
Z. Gerhart-Hines, J.E. Dominy, S.M. Blättler, M.P. Jedrychowski, A.S. Banks, J.H. Lim, H. Chim, S.P. Gygi andP. Puigserver
Molecular Cell. 44(6):851-63, 2011

A hypoxia induced positivefeedback loop promotes HIF-1α stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like
T.J. Kelly, A. Souza, C. Clish and P. Puigserver
Mol. Cell Biol. 31(13):2696-2706, 2011

Clk2 and B56β mediate insulin regulated assembly of the PP2A holoenzyme Complex on Akt
J.T. Rodgers, R. Voegel and P. Puigserver
Molecular Cell. 41(4):471-9, 2011

Nuclear chromatin factors defining mitochondrial bioenergetics: implications in age-associated diseases
P. Puigserverand L. Guarente
In: Mitochondrial Signaling in Health and Diseases. Edited by Sten Orrenius and E. Cadenas. 2011

Nutrient-dependent acetylation controls basic regulatory switches and cellular reprogramming
J. E. Dominy, Z. Gerhart-Hines and P. Puigserver
Cold Spring Harb Symp Quant Biol.76:203-9, 2011

PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis
K. Bhalla, B.J. Hwang, R. Dewi, L. Ou, W. Twaddel, H.B. Fang, S. Vafai, F. Vazquez, P. Puigserver, L.G. Boros and G. Girnun
Cancer Res. 71(21):6888-98, 2011

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function
K. Romanino, L. Mazelin, V. Albert, A. Duplany, S. Lin, C.F. Bentzinger, C. Handschin, P. Puigserver, L. Schaeffer, Y.G. Gangloff and M. Ruegg
Proc. Natl. Acad. Sci. USA. 108(51):20808-13, 2011

2010

Cdc2-like kinase 2 is an insulin regulated suppressor of hepatic gluconeogenesis.
J.T. Rodgers, W. Haas, S.P. Gygi and P. Puigserver
Cell Metabolism. 11(1), 23-34, 2010

Nutrient-dependent regulation of PGC-1alpha’s acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5
J.E. Dominy, Y. Lee, Z. Gerhart-Hines and P. Puigserver
Biochim Biophys Acta. 1804(8):1676-83, 2010

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
A.K. Walker, F. Yang, K. Jiang, J.Y. Ji, J.L. Watts, A. Purushotham, O. Boss, M.L. Hirsch, S. Ribich, J.J. Smith, K. Israelian, C.H. Westphal, J.T. Rodgers, T. Shioda, S. Elson, P. Mulligan, H. Najafi-Shoushtari, J.C. Black, J.K. Thakur, L.C. Kadyk, J. Whetstine, R. Mostoslavsky, P. Puigserver, X. Li, N.J. Dyson, A.C. Hart, and A.M. Näar Genes Dev. 24(13):1403-17, 2010

Nuclear FoxO1 inflames insulin resistance
J. Dominy and P. Puigserver
EMBO J. 29:4068-9, 2010

2009

GCN5-mediated transcriptional control of the metabolic coactivator PGC-1β through lysine acetylation.
T.J. Kelly, C. Lerin, W. Haas, S.P. Gygi, and P. Puigserver
J. Biol. Chem. 284(30):19945-52, 2009

Foxo1 integrates insulin signaling with mitochondria function in the liver
Z. Cheng, S. Guo, K. Copps, X. Dong, R. Kollipara, J.T. Rodgers, R.A. DePinho, P. Puigserver and M.F. White
Nature Medicine. 15(11):1307-11, 2009

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachments
Z.T. Schafer, A.R. Grassian, L. Song, Z. Jiang, Z. Gerhart-Hines, H.Y. Irie, S. Gao, P. Puigserver and J. S. Brugge
Nature. 461(7260):109-13, 2009

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
C. Canto, Z. Gerhart-Hines, J.N. Feige, M. Lagouge, J.C. Milne, L. Noriega, P.J. Elliott, P. Puigserver and J. Auwerx
Nature. 458(7241):1056-60, 2009

Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
G. Suchankova, L. Nelson, Z. Gerhart-Hines, M. Kelly, M.S. Gauthier, A.K Saha, Y. Ido, P. Puigserver and N.B. Ruderman
Biochem. Biophys. Res. Commun. 378:836-41, 2009

2008

Metabolic adaptations  through PGC-1α and SIRT1 pathways
J. T. Rodgers, C. Lerin, Z. Gerhart-Hines and P. Puigserver
FEBS Letters. 582: 46-53, 2008

A PGC-1a:O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose
M.P. Housley, N.D. Udeshi, J.T. Rodgers, J. Shabanowitz, P. Puigserver, D.F. Hunt and G.W. Hart
J. Biol. Chem. 284(8):5148-57, 2008

The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1α
A. Coste, J.F. Louet , M. Lagouge , C. Lerin , M. Antal , H. Meziane , K. Schoonjans , P. Puigserver, B. O’Malley and J. Auwerx
Proc. Natl. Acad. Sci. USA. 105(44):17187-92, 2008

O-GlcNAc regulates FoxO activation in response to glucose
M.P. Housley, J.T. Rodgers, N.D. Udeshi, T.J. Kelly, J. Shabanowitz, D.F. Hunt, P. Puigserver and G.W. Hart
J. Biol. Chem. 283(24):16283-92, 2008

2007

mTOR controls mitochondrial oxidative function through a YY1/PGC-1α complex
J.T. Cunningham, J.T. Rodgers, D. Arlow, F. Vazquez, V.K. Mootha and P. Puigserver
Nature. 450, 736-740, 2007

Fasting-dependent glucose and lipid metabolic response through hepatic SIRT1
J.T. Rodgers and P. Puigserver
Proc. Natl. Acad. Sci. USA. 104(31) 12861-66, 2007

Metabolic control of mitochondrial function and fatty acid oxidation through PGC-1α /SIRT1
Z.Gerhart-Hines, J.T. Rodgers,O. Bare, C. Lerin, S.H. Kim, R. Mostoslavsky, F.W. Alt, Z. Wu and P. Puigserver
EMBO J. 26, 1913-1923, 2007

Mammalian metabolism in aging
P. Puigserverand C.R. Kahn
Edited by L. Guarente, L. Partridge and D.C. Wallace
Molecular Biology of Aging. Cold Spring Harbor Monograph Series 51. 2007

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
D. Kim, M.D. Nguyen, M.M. Dobbin, A. Fisher, F. Sananbesi, J.T. Rodgers, I. Delalle, J.A. Baur, G. Sui, S.M. Armour, P. Puigserver, D.A. Sinclair and L.H. Tsai
EMBO J. 26(13):3169-79, 2007

Receptor feasts on sugar and cholesterol
J. T. Rodgers and P. Puigserver
Nature Medicine. 13(2):128-129, 2007

2006

GCN5 acetyl transferase complex controls glucose metabolism through transcriptional repression of PGC-1α
C. Lerin, J.T. Rodgers, D. Kalume, S.H. Kim, A. Pandey andP. Puigserver
Cell Metabolism. 3(6):429-38, 2006

Resveratrol promotes mitochondrial biogenesis and protects against metabolic disease through activating SIRT1 and PGC-1α activity
M. Lagouge, C. Argmann, Z. Gerhart-Hines, H. Meziane, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, C. Lerin, B. Geny, M. Laakso, P. Puigserver and J. Auwerx Cell. 127(6):1109-22, 2006

Resveratrol improves health and survival of mice on a high-calorie diet
J.A. Baur, K.J. Pearson, N.L. Price, H.A. Jamieson, C. Lerin, A. Kalra, V.V. Prabhu, J.S. Allard, G. Lopez-Lluch, K. Lewis, P.J. Pistell, S.Poosala, K.G. Becker, O. Boss, D. Gwinn, M. Wang, S. Ramaswamy, K.W. Fishbein, R.G. Spencer, E.G. Lakatta, D. Le Couteur, R.J. Shaw, P. Navas, P. Puigserver, D.K. Ingram, R. de Cabo and D.A. Sinclair
Nature. 444(7117):337-42, 2006

Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: role of PGC-1α
S.H. Cha, J.T. Rodgers, P. Puigserver, S. Chohnan and M.D. Lane
Proc. Natl. Acad. Sci. USA. 103(42):15410-5, 2006

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer’s disease and amyloid neuropathology by calorie restriction
W.Qin, T. Yang, L. Ho, Z. Zhao, J. Wang, L. Chen, M. Thiyagarajan, D. Macgrogan, J.T. Rodgers, P. Puigserver, J. Sadoshima, H.H. Deng, S. Pedrini, S. Gandy, A. Sauve and G.M. Pasinetti
J. Biol. Chem. 281(31):21745-54, 2006

Foxa2, a novel transcriptional regulator of insulin sensitivity
P. Puigserver and J.T. Rodgers
Nature Medicine. 12(1):38-9, 2006

Certainly you can’t live without it: SIRT6
J. T. Rodgers and P. Puigserver
Cell Metabolism. 3(2):77-8, 2006

2005

Nutrient control of gluconeogenesis through PGC-1α/SIRT1 deacetylase complex
J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman and P. Puigserver
Nature. 434:113-8, 2005

Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC-1α
P. Puigserver
Int. J. Obes. Relat. Metab. Disord. 29: S5-9, 2005

1991-2004

PGC-1α: Metabolic Regulator and Transcriptional Coactivator
B.M. Spiegelman and P. Puigserver
Endocr. Rev. 24(1): 78-90, 2003

ERRα and Gabpα/β specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
V.K. Mootha, C. Handschin, D. Arlow, X. Xie, J. St Pierre, S. Sihag, W. Yang, D. Altshuler, P. Puigserver, N. Patterson, P.J. Willy, I.G. Schulman, R.A. Heyman, E.S. Lander and B.M. Spiegelman
Proc. Natl. Acad. Sci. USA. 101:6570-5, 2004

p38 mitogen-activated protein kinase is the central regulator of cAMP-dependent transcription of the brown fat uncoupling protein 1 gene
W. Cao, K.W. Daniel, J. Rabidoux, P. Puigserver, A.V. Medvedev, X. Bai, L.M. Floering, B.M. Spiegelman and S. Collins
Mol. Cell Biol. 24:3057-3067, 2004

Suppression of mitochondrial respiration via p160 Myb binding protein docking on PGC-1α: modulation by p38 MAPK
M. Fan, J. Rhee, J. St-Pierre, C. Handshin, P. Puigserver, J. Lin, S. Jaeger, H. Erdjument-Bromage, P. Tempst and B.M. Spiegelman
Genes Dev. 18: 278-289, 2004

Suppression of beta-cell energy metabolism and insulin release by PGC-1α
J. Cliff Yoon, G. Xu, J.T. Deeny, S. Yang, J. Rhee, P. Puigserver, R. Yang, C. Zhang, B.B. Lowell, P.O. Berggren, C.B. Newgard, S. Bonner-Weir, G. Weir and B.M. Spiegelman
Dev. Cell. 5, 73-83, 2003

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
V.K. Mootha, C.M. Lindgren, K.F. Eriksson, A. Subramanian, S. Sihag, P. Puigserver, E. Carlsson, M. Ridderstrale, E. Laurila, N. Houstis, M.J. Daly, N. Patterson, J.P. Mesirov, T.R. Golub, P. Tamayo, B.M. Spiegelman, E.S. Lander, J.N. Hirschhorn, D. Altshuler and L.C. Groop
Nat. Genet. 34, 267-273, 2003

PGC-1β in the regulation of hepatic glucose and energy metabolism
J. Lin, P.T. Tarr, R. Yang, J. Rhee, P. Puigserver, C.B. Newgard and B.M. Spiegelman J. Biol. Chem. 278, 30843-8, 2003

Insulin-regulated hepatic gluconeogenesis through FOXO1/PGC-1α interaction
P. Puigserver, J. Rhee, J. Donovan, C.J. Walkey, J.C. Yoon, F. Oriente, Y. Kitamura, J. Altomonte, H. Dong, D. Accili and B.M. Spiegelman
Nature. 423, 550-5, 2003

Regulation of hepatic fasting response by PPARgamma coactivator-1 alpha (PGC-1α): Requirement for hepatocyte nuclear factor 4 alpha in gluconeogenesis
J. Rhee, Y. Inoue, J.C. Yoon, P. Puigserver, M. Fan, F.J. Gonzalez and B.M. Spiegelman
Proc. Natl. Acad. Sci. USA. 100, 4012-7, 2003

Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC-1α) expression in the murine brain
N.A. Tritos, J.W. Mastaitis, E.G. Kokkotou, P. Puigserver, B.M. Spiegelman and E. Maratos-Flier
Brain Res. 961, 255-60, 2003

Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibers
J. Lin, H. Wu, P. Tarr, C.Y. Zhang, Z. Wu, O. Boss, L.F. Michael, P. Puigserver, E. Isotani, E. N. Olson, B. Lowell, R. Bassel-Duby and B.M. Spiegelman
Nature. 418, 797-801, 2002

PGC-1β: A novel transcription coactivator associated with host cell factor
J. Lin, P. Puigserver, J. Donovan, P. Tarr and B.M. Spiegelman
J. Biol. Chem. 277, 1645-1648, 2002

Cytokine-activation of energy expenditure through p38 MAP kinase phosphorylation of the PPARγ coactivator (PGC-1)
P. Puigserver, J. Rhee, J. Lin, Z. Wu, J.C. Yoon, C. Zhang, S. Krauss, V. Mootha. B.B. Lowell and B.M. Spiegelman
Mol. Cell. 8, 971-982, 2001

CREB regulates hepatic gluconeogenesis via the co-activator PGC-1
S. Herzig, F. Long, U. Jhala, S. Hedrick, R. Quinn, A. Bauer, D. Rudolph, G. Schutz, J.C. Yoon, P. Puigserver, B.M. Spiegelman and M. Montminy
Nature. 413:179-183, 2001

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
J.C. Yoon, P. Puigserver, G. Chen, Z. Wu, J. Rhee, G. Adelmant, J. Stafford, C.R. Kahn, K. Granner, C.B. Newgard, and B.M. Spiegelman
Nature. 413:131-138, 2001.

Restoration of insulin-sensitive glucose transporter (GLUT-4) gene expression in muscle cells by the transcriptional coactivator PGC-1
L.F. Michael, Z. Wu, R.B. Cheatham, P. Puigserver, G. Adelmant, J.J. Lehman, D.P. Kelly, and B.M. Spiegelman
Proc. Natl. Acad. Sci. USA. 98:3820-3825, 2001

Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1
M. Monsalve, Z. Wu, G. Adelmant, P. Puigserver, M. Fan, and B.M. Spiegelman
Mol. Cell.  6:307-316, 2000

Regulation of adipogenesis and energy balance by PPARγ and PGC-1
B. M. Spiegelman, P. Puigserver and Z. Wu
Int. J. Obes. Relat. Metab. Disord. 24 (4): S8-10, 2000.

Regulation of adipogenesis and energy balance by PPARγ and PGC-1
I. Tcherepanova, P. Puigserver, J. Norris, B.M. Spiegelman and D. McDonnell
J. Biol. Chem. 275 (21) 16302-16308, 2000

Transcriptional regulation of adipogenesis
E.D. Rosen, C.J. Walkey, P. Puigserver and B.M. Spiegelman
Genes Dev. 14: 1295-1307, 2000

Activation of PPARγ Coactivator (PGC-1) through transcription factor docking
P. Puigserver, G. Adelmant, Z. Wu, M. Fan, J. Xu, B. O’Malley and B.M. Spiegelman
Science. 286(5443):1368-71,1999
 

Transcriptional activation of adipogenesis
Z. Wu, P. Puigserver and B. M. Spiegelman
Curr. Opin. Cell Biol. 11(6): 689-94, 1999

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
Z. Wu, P. Puigserver, U. Andersson, C. Zhang, G. Adelmant, V. Mootha, A. Troy, S. Cinti, B. Lowell, R. Scarpulla and B.M. Spiegelman
Cell. 98:115-24, 1999

Stimulation of uncoupling protein 1 expression in brown adipocyte by naturally occurring carotenoids
F. Serra, M.L. Bonet, P. Puigserver, J. Oliver and A. Palou
Int. J. Obes. Relat. Metab. Disord.  23:650-5, 1999

Regulation of energy balance by PPARγ and its coactivators
B.M. Spiegelman, G. Castillo, S. Hauser and P. Puigserver
Progress in Obesity Research: 8, 39-46, 1999

A cold-inducible nuclear receptor coactivator linked to adaptive thermogenesis
P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright and B.M. Spiegelman
Cell. 92, 829-839, 1998

Involvement of the retinoblastoma protein in brown and white adipocyte cell differentiation: functional and physical association with the adipogenic transcription factor C/EBPα
P. Puigserver, J. Ribot, F. Serra, M. Gianotti, M.L. Bonet, B. Nadal-Ginard and A. Palou
Eur. J. Cell Biol.  77(2), 117-123, 1998          

2-methoxyoestradiol, an endogenous metabolite of 17-β-estradiol, inhibits adipocyte proliferation
C. Pico, P. Puigserver, P. Oliver and A. Palou
Mol. Cell. Biochem. 189, 1-7, 1998

Retinoic acid modulates RARα and RXRα levels in cultured brown adipocytes
M.L. Bonet, P. Puigserver, F. Serra, F. Vazquez, C. Pico and A. Palou
FEBS Lett.  406, 196-200, 1997

Diminished response to food deprivation of the rat brown adipose tissue mitochondrial uncoupling system with age
F.J. Garcia-Palmer, J. Pericas, J.C. Matamala, P. Puigserver, M.L. Bonet, A Palou and M. Gianotti
Biochem. Mol. Biol. Int. 42, 1151-1161, 1997

In vitro an in vivo induction of the uncoupling protein thermogenin by retinoids
P. Puigserver, F. Vazquez, M.L. Bonet, C. Pico and A. Palou
Biochem. J. 317, 827-833, 1996

Effect of selective ß-adrenoceptor stimulation on UCP expression in primary cultures of brown adipocytes
P. Puigserver, C. Pico, M.J. Stock and A. Palou
Mol. Cell Endocrinol. 117, 7-16, 1996

Cold exposure induces different uncoupling-protein thermogenin masking/unmasking processes in brown adipose tissue depending on mitochondrial subtypes
M. Moreno, P. Puigserver, J. Llull, M. Gianotti, A. Lanni, F. Goglia and A. Palou
Biochem. J. 300, 2, 463-468, 1994

Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in-vitro and in-vivo: evidence for a rapidly degradable pool
P. Puigserver, D. Herron, M. Gianotti, A. Palou, B. Cannon and J. Nedergaard
Biochem. J. 284, 393-398, 1992

Dietary regulation of fasting-induced mitochondrial protein degradation in adult rat brown adipose tissue
P. Puigserver, A. Palou and M. Gianotti
Biochem. Int. 27, 1037-1046, 1992

Impaired starvation-induced loss of mitochondrial protein in the brown adipose tissue of dietary obese rats
P. Puigserver, A. Palou and M. Gianotti
Int. J. Obes. 16, 255-261, 1992

Adrenergic regulation of differentiation and proliferation in brown adipocyte cultures
J. Nedergaard, M. Néchad, S. Rehnmark, D. Herron, A. Jacobsson, P. Kuusela, P. Puigserver, J. Houstek, G. Bronnikov and B. Cannon
Obesity in Europe. G. Ailhaud et al. Eds. 355-361,1991

Evidence for masking of rat brown adipose tissue mitochondrial GDP-binding sites in response to fasting in rats made obese by dietary manipulation
P. Puigserver, I. Llado, A. Palou and M. Gianotti
Biochem. J. 279, 575-579, 1991